Oh, this is some of my friends asked, I made some simple answer, because the specific equipment and processes depends on the difference, then make some adjustments to the corresponding. Oh, there may be problems this group of colleagues is no stranger to it, because the same set of questions may also be asked several of our senior technical staff, alas! Perhaps few of us the answer is the standard of the cross.
1, SC large-scale production, the temperature at 30 degrees below room temperature at 30 degrees or more, do get it? What are the requirements of the condensate?
A: The temperature at 30 degrees below, you can control that, if use of groundwater, or condensing heat exchanger using water temperature can also drop off.
2, SC in large-scale production, particle size testing instruments need to complete it? Also need to measure what the instrument or test which indicators?
A: Yes, with a particle size analyzer, without conditions, if the fixed species and processes, grinding the slurry to send in the vicinity of the detection unit for inspection, sorting out the number and size of the abrasive relationship between the future is business as usual. Particle detector is basically the main instrument.
3, SC, when large-scale production, the added amount of defoamer is how to control and determined? To what extent to remove the bubble can only be packing?
A: The beginning part of the deployment are added to the slurry, the slurry after grinding later observed bubbles situation. If increased significantly and difficult to eliminate, as part of continuing additional defoamer. Basically, in order to eliminate the bubble does not affect the extent of the standard cans, for example: 200ML bottles fitted 200G, found in or near the bottleneck of the overflow is still needed on the defoaming products.
4, large-scale production SC, sanding there creaming What causes this? How to solve it?
A: The direct and formulation screening of a great relationship, not the best optimized formulation screening point. But in the process of large-scale production problems exposed.
5, SC packaging materials are no restrictions or how to choose?
A: SC package no special restrictions on the basic material, commonly used bottle is possible.
6, SC large-scale production, if the original drug into particles or a large block, need to pre-crushed (jet mill) it?
Homogeneous machine or directly into homogeneous?
A: The discovery of the original drug in large particles and block the original drug, it is best not to directly feed, easy to damage your machine or homogeneous locking motor burn. Generally require pre-crushing machinery like, not necessarily the air, you can crush the ordinary.
7, SC return if there is how to solve quality problems? (Agglomeration, stratification)
A: unpacking, ready to rework. Packaging materials, transportation, labor, wear and tear is inevitable. Analysis of hierarchical agglomeration of the reasons that have been layered slurry for processing. If the large particles, you need to re-sanding, Pour the clear liquid, the lower recovery of the active ingredient, the final concentration in the sample test, re-determine the content of preparation. If the slurry to flow, little change in size, to analyze whether or corruption caused by the lack of thickeners, fungicides may be additional thickener solution.
8, suspended emulsion (SE) processes which are now the most popular? (By hanging tricyclazole propiconazole emulsion, for example)
9, laboratories SC configuration, the material than how much? (We generally use 1:1-1:2)
10, large-scale production SC, three sanding is how to do is two or three series it is a cycle?
A: We are using imported sand mill, grinding efficiency is much higher than domestic. General domestic line is at least two series sanding, if the conditions that three series, set different grinding accuracy and efficiency.
11, large-scale production SC, the weather temperature (temperature above 35 degrees or below 10 degrees cold) What is the impact of processing?
A: The temperature is generally not much of an impact, only a positive effect.High temperature, then easily lead to evaporation of water, bubbles increased, the slurry temperature is too high, causing the cream of the phenomena.
12, SC formula, why not use PVA as a thickening agent (I think the pva color is good, but also to prevent coagulation)? PVA solution process is complicated reason?
A: The trouble is not dissolved, because as a thickener xanthan gum thickening effect a good, easy to use. So rarely use PVA, unless made in a number of FS in the film former (and be vigilant, because the harm likely to lead to closed types).
13, SC formulations, with a strong dielectric (high concentration) as the dispersion medium (the application has affected the additives), how to choose the right agent? (Glyphosate salt solution to make media)
A: There is no good way, only you do more screening formula, whether or thickening agent system, system of high-electrolyte systems are not ideal.
14, I have tested the seed coat of different companies at home and abroad suspension products, domestic general place six months to a size 70-100um, foreign countries can also control the 5UM below. It can be seen, the domestic chaos and the quality varies greatly additives, the additives in China to develop? Haha.
用菊子曰写博客，就是爽！
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