Dinotefuran research and development concern

Given Dinotefuran good market prospects and applications for domestic and foreign varieties of pesticides features faster updates, relevant domestic agencies should increase Dinotefuran research and development efforts, increase the new neonicotinoid insecticide create work . 

       Dinotefuran East Chemical Co., Ltd. is Japan's Mitsui development, and in 2002 listed the new neonicotinoid insecticide. It is the only non-chlorine pesticides, alkali atoms and aromatic rings, called third-generation neonicotinoid insecticide, has a super-efficient, broad-spectrum, with less toxicity is low (slightly toxic preparation level), lasting effect, without injury to crops, the use and safety. With the Chinese market in the near future, the patent is about to expire, Dinotefuran with good prospects for the development and application, should attach great importance to the industry. 

        Special structure and excellent performance. Dinotefuran other neonicotinoid insecticides with different structures, characteristic of the (±) tetrahydro -3-- methyl furan structure, rather than all the other neonicotinoid-based material has the pyridine structure. As the special structure, performance, compared with more traditional neonicotinoid insecticides excellent, not only in rice, vegetables, fruit trees, flowers on the Hemiptera, Lepidoptera, Diptera, Hymenoptera beetles and the total head pests efficient, and effective on the pests have become a very promising development, structural novelty, there may be a large world-wide variety of pesticides. 

        Demand prospects. Neonicotinoid insecticides on the market to become mainstream in recent years, domestic and foreign varieties of pesticides and good momentum of development, imidacloprid, acetamiprid, nitenpyram, imidaclothiz, thiacloprid, have already produced domestically; pesticides "four kings" is one of fogo new neonicotinoid insecticide thiamethoxam and new varieties of insects benzamide compound of chlorine products, as domestic rice fields one of the largest amount of pesticides. It is predicted that by 2012, global neonicotinoid insecticide sales will reach $ 2.5 billion, jumped to the entire class of pesticides will be the first of pesticides. Neonicotinoid insecticides not only environmentally friendly, low toxicity, and is consistent with the national conditions of China's crop, a new neonicotinoid insecticide can control the various varieties of rice insect pests. Rice is the first major crop, planted area of ​​43,000 acres, domestic rice prices soared in recent years, rice yield and quality by the state's attention, no doubt greatly promote a new neonicotinoid insecticide market demand; the same time, a ammonium phosphate, five kinds of highly toxic pesticides delisting, the disabled Fipronil insecticide to the domestic market leaving a huge supply gap. In recent years, foreign multinational giants vied for pesticide paddy field pesticide market is indicative of the potential of the domestic market attractive. As countries continue to increase environmentally unfriendly pesticides remediation efforts, the development will bring new neonicotinoid pesticides historic opportunity. 

        Resistance factor is low. With the neonicotinoid pesticides widely promoted, many pest species on the main neonicotinoid pesticide imidacloprid has generated a certain amount of resistance, the data reported shows that in a region already acetamiprid and Nitenpyram also had a resistance. Furosemide is not yet listed as the first generation of pyridine amine neonicotinoid insecticide alternative varieties, the future does not exist within a short time a similar problem. 

        Patents about to expire. Dinotefuran since 2002 in Japan, in 2005 in the United States, then in Europe, 2012 listed in mainland China, the patent expired in 2014, currently doing the preparatory work should begin. 

Research has been based. Currently part of the research structure has been carried out Dinotefuran and synthesis intermediates, synthetic route as reported in the literature many domestic research focused on the malonate and ethyl bromoacetate as the starting material for synthesis of 3 - tetrahydrofuranmethanol and further prepared by reacting an important intermediate 3 - tetrahydrofuran methylamine, then the other intermediate O-methyl-N-nitro-N '- phthalimido different urea synthesis furosemide pyridine amine. Currently has three companies Jiangsu, Zhejiang industrial production Dinotefuran key intermediate 3 - tetrahydrofuran methylamine, and export reports, the quality of products fully meet the foreign production Dinotefuran requirements. 

        Given Dinotefuran good market prospects and applications for domestic and foreign varieties of pesticides features faster updates, relevant domestic agencies should increase Dinotefuran research and development efforts, and Dinotefuran and with other common pesticides agents such as pyrethroids, organophosphate, carbamate complex with the study of imitation at the same time, should learn from foreign advanced experience, increase new neonicotinoid insecticide create work.

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