Feasibility report Mesotrione

One. Products

Mesotrione, English common name: mesotrion, test, code-named ZA1296, chemical name: 2 - (4 - methyl sulfonyl 2 - nitro - benzoyl) cyclohexane -1,3 - dione, the application No. [104206-82-8], the English name for: 2 - [4 - (methylsulfonyl)-2-nithobenzoyl] -1,3-cyclohexanedione. Syngenta has developed a three herbicides, and the trade name callisto (Artemis pass) in 2001 in Europe.

Structure:

Molecular formula: C14H13NO7S; Weight: 339

Physical and chemical properties: the original drug to dark solid, pure product is white crystalline powder, melting point 165 ℃. Vapor pressure of 4.27 × 10-8mmHg (20 ℃), PH5-9 solution in the stable.

Toxicity: male, female rats acute oral LD50> 5000mg/kg, rat acute dermal LD50> 2000mg/kg, acute inhalation LC50 (4h)> 5mg / L, non-carcinogenic. No crop residue harvest after inspection of birds, mammals and aquatic plants do not constitute a hazard.

Mechanism:

Inhibition of hydroxy pyruvate dioxygenase (HPPD) activity. HPPD amino acid tyrosine can be converted into plastoquinone, which is eight hydrogen lycopene desaturase cofactor, is a key carotenoid biosynthetic enzymes. Use within 3-5 days Mesotrione meristem plants yellowing symptoms appear, followed by necrotic lesions caused by, two weeks throughout the whole plant. Mesotrione a weak acid, the most acidic soil, can not easily be absorbed mainly in the anionic form. This product can quickly degrade a wide range, and the final metabolite of carbon dioxide, the average soil half-life of 9 days, with rapid degradation in the soil, and low consumption.

Suitable crops and the safety of the crop:

After a broadleaf herbicide corn bud bud, there is the suction, can effectively control annual broadleaf weeds in corn and some grass weeds, not only the safety of corn, but also for the environment, post-crop safety.

Control target:

Broad-spectrum herbicide, such as Control in velvetleaf can, Xanthium, Amaranthus spinosus, quinoa is a weed, Kochia scoparia, Polygonum weeds, mustard, barnyard grass, chickweed, crabgrass and other weeds on the sulfonylurea herbicide resistant weeds effectively.

Usage:

After the bud and the bud can be used, alone dose: bud is 100-225gai/ha, buds after 70-150 gai / ha. To expand the weed spectrum weed control with acetochlor mixed bud, bud after the weeding can be mixed with nicosulfuron.

II. Market Situation and Prospects

Mesotrione is Syngenta's products, the product has passed the patent period, but in China, administrative protection, administrative protection period to 2011, the product sales in 2006 more than 3 billion U.S. dollars. Because the patent has expired, the export of the product in great demand. Currently there are few manufacturers in the production and export, also made some preparations in domestic sales.

Billion in 2004 global sales of pesticides on the species (USD)

Herbicides (total 34)

Glyphosate 31.85 (29.33) Acetochlor 4.5 (4.3) Metolachlor 3.85 (2.95)

Paraquat 3.85 (3.75) 2,4 - 3.05 (2.90) oxazoline diclofop 2.95 (2.55)

Atrazine 2.95 (2.60) pendimethalin 2.80 (2.25) Mesotrione 2.70 (1.80)

Glufosinate 2.45 (1.80) parathion grass 2.10 (1.95) trifluralin 2.00 (1.90)

Imazethapyr 2.00 (1.80) Dicamba 2.00 (1.55) propargyl ester grass 1.95 (1.75)

Nicosulfuron 1.80 (1.85) 1.75 picolinate amlodipine (1.50) 1.60 fluroxypyr (1.15)

Clethodim 1.35 (1.20) Diquat pine 1.35 (1.25) 1.30 ethyl sulfone (1.05)

Chlorimuron-ethyl 1.25 (0.70) F diclofop fine pyridine 1.25 (1.35) Wo Jing Ling fluoride pyridine 1.25 (1.15)

Bensulfuron 1.20 (1.40) 1.20 metsulfuron (1.40) grass pyridine 1.20 (1.05)

Isoproturon 1.10 (0.70) 2 A 4 Cl 1.10 (0.65) Diuron 1.05 (0.75)

Bromoxynil 1.05 (0.90) hexazinone 1.00 (0.90) butachlor 1.00 (0.95)

Pesticides (Total 22)

Imidacloprid 8.2 (6.65) chlorpyrifos 3.90 (3.5) thiamethoxam 2.98 (2.15)

Fipronil 2.85 (2.4) deltamethrin 2.30 (1.95) cypermethrin 2.10 (1.10)

Cypermethrin 1.95 (1.80) hits 1.80 (1.05) spinosad 1.70 (1.35)

Abamectin 1.65 (1.50) of bifenthrin 1.45 (1.20) endosulfan 1.40 (1.15)

Aldicarb 1.35 (1.20) methomyl 1.30 (1.15) Carbofuran 1.20 (0.95)

Acephate 1.10 (0.85) 1.10 profenofos (1.10) cis-cypermethrin 1.10 (1.10)

Dimethoate 1.05 (0.95) malathion 1.00 (0.85) S-fenvalerate 1.00 (1.00)

Bacillus thuringiensis 1.00 (1.05)

Fungicides (19 total)

Tebuconazole 5.75 (3.6) azoxystrobin 5.05 (4.10) Epoxiconazole 3.95 (2.80)

Mancozeb 3.40 (2.90) 2.95 yl ester amine bacteria (0.85) oxime ester bacteria 2.55 (2.25)

Chlorothalonil 2.40 (2.10) 2.25 copper formulations (1.65) metalaxyl 1.90 (1.70)

Kresoxim 1.83 (1.65) fosetyl Al 1.23 (1.20) Difenoconazole yl 1.25 (1.10)

Carbendazim 1.25 (0.85) iprodione 1.15 (1.05) cymoxanil 1.10 (0.85)

Allyl isothiazole 1.00 (0.90)

III. Product synthesis

A) The synthetic route

B) Synthesis

Mainly of a sulfone toluene, thionyl chloride, cyclohexanedione as the main raw material, through nitration, oxidation, chlorination, condensation, reduction of refined derived from a total of four-step reaction, nitration and oxidation of two-step yield of 68% , acylation and condensation two-step yield of 70%. The original drug content over 95%, yellow solid. Product synthetic raw material costs at 13 yuan / ton.

C) Major Equipment: (in annual output of 100 tons)

1, the mixed acid preparation station tank 1000L 1

2, the nitrification tank 2000L 1 table

3, the oxidation tank 1000L 1 table

4, the crystallization vessel 1000L 1 table

5, the preparation of nitric acid, sulfuric acid distillation units kettle 3000L 1

6, sub-units of sodium preparation tank 1000L 1

7, acylation tank 3000L 1 table

8, synthesis reactor 3000L 1 table

9, crystal stills 1000L 1 table

10 recovery tank 3000L 1 triethylamine Taiwan

11, gas absorption tank 2000L 1 Taiwan Taiwan 3000L 1

12, measuring tank, dropping cans, receiving tank: 400l \ 500L \ 1500L \ 3000L of the 2 sets, 1000L, 2000L of the 4, the main material for the ceramic, enamel or plastic

13, Other: nitric acid storage tank, acid storage tank 20 1 set of each cube, the square of the condenser 20, 5, SS1000 1 set centrifuges, equipment investment of 100 million. The total investment is supporting the case under the public works.

14, need to vacuum, refrigeration, steam cycle, water and other public works, the maximum temperature of 160 degrees, have a need for heating oil. 10 million kilocalories of a refrigeration system (-20 ℃).

D) The waste situation

Production process will produce SO2, NO, HCL and other gases, required alkali, sodium sulfite absorption, produce about 20 tons per ton of waste products, which contain 7-8 tons of waste acid, can supply fertilizer company.

IV. Economic Benefit Analysis

Mesotrione 13 million production cost of raw materials / ton, the raw material production and management costs are about 1.3 times. Mesotrione the production cost of 17 yuan / ton. Market price of the product is now more than 40 yuan / ton (44-46 yuan / ton), the product profit of more than 20 yuan / ton to 100 tons calculation, the net profit a year more than 2000 million.