Diniconazole

Diniconazole 

CAS Number: 83657-24-3 

English name: Diniconazole 

Chemical Name: E-(R, S) -1 (2,4 - dichlorophenyl) -4,4 - dimethyl -2 - (1H-1, 2,4 - three oxazole -1-- yl) E -1-- en -3-- alcohol; (e) -1 - (2,4,-dichlorophenyl) -4,4-dimethyl-2-(1,2,4-triazole-1-yl) 1-pentenyl- 3-ol; 

Other Names: Dake Li; off the black spirit; special off yl; Trapp yl; Zhuang Ling Mak 

Molecular formula: C15H17Cl2N3O 

MW: 326.22 

Structure: 

Properties: colorless crystalline solid the original drug. Melting point of about 134 至 156 ℃, vapor pressure 2.93mPa (20 ℃), 4.9mPa (25 ℃), density of 1.32 (20 ℃), Solubility: 25 ℃ water, 4.1mg / L, 23 ℃ methanol 95g/kg, xylene 14g / kg, acetone 95g/kg, hexane 700mg/kg 

Toxicity: the original drug in male rats acute oral LD50953mg/kg, female 570mg/kg; rat acute dermal LD50> 2000mg/kg; rat acute inhalation LC50> 2770mg/m3. Mildly stimulating effect on the eyes. Sub-chronic toxicity test in rats had no effect concentration of 100mg/kg. Ames test results were negative. Carp LC504.0mg / L (96h), duck LD50> 2000mg/kg, quail LD501490mg/kg. 

Role of the characteristics and uses: azole fungicides, sterol demethylation inhibitors. Both the protection, treatment, elimination of the role, another broad-spectrum, the absorption, the top of the conduction antifungal activity. Of ascomycetes, basidiomycetes and imperfect fungi diseases, such as rust, powdery mildew, black spot and Cercospora diseases has a good effect. Will use 20 ~ 40g 100kg seed seed treatment active ingredient, can prevent smut cereal crops, Xingheisuibing; active ingredients with the dressing 15 ~ 20g, you can control powdery mildew, stripe rust, stem rust, stem rust, cloud grain disease, leaf blight; foliar spraying 0.225 ~ 0.6g active ingredient / 100 m2, can prevent cereals powdery mildew, stripe rust, leaf rust. In addition, can also be used to control grape powdery mildew, apple black fishy diseases, rust and powdery mildew, peanuts early and late leaf spot can also Control in white stem rot and rust. Period before the onset of spraying should be the latest in the early stages of disease should also be used. 

Formulation: 25% Diniconazole EC, EC Diniconazole 12.5%, 10% Diniconazole EC, 12.5% Diniconazole WP, 5% Diniconazole microemulsion, 5% Diniconazole dry seed coating 

Production Methods: The quantitative triazole, sodium hydroxide, toluene on the reactor, heating, refluxing, to the water, when the temperature reaches 110 ℃, down 50 ℃, adding quantitative pinacolone chloride at 70 ~ 75 ℃ reaction 5h, cooling and filtering, part of the solution de-soluble trazodone. Trazodone do purified by first adding concentrated hydrochloric acid generated trazodone hydrochloride, together with dilute alkaline solution and to pH 6 ~ 7. Will trazodone solution, 2,4 - dichlorobenzene formaldehyde and the catalyst back to the water temperature by adding the quantitative mixing acid at 50 ℃ 30min, standing layers, the organic phase was mixed ketene vacuum precipitation, combined with quantitative chlorine Benzene aside. Then mixed ketene isomerization, add sulfuric acid and bromine, in the 80 ~ 85 ℃ reaction 6h, plus cake and solvent water kettle, stirring hydrolyzed at 50 ℃, the upper organic phase precipitation, diluted with methanol, was E - enol methanol solution. Finally, the E-enone methanol solution, in 5 ~ 10 ℃, the addition of potassium borohydride, plus completion of the following reaction at 25 ℃ for 5h, reducing end, off the solvent was added dilute acid hydrolysis, acidification, cooling, drying, After drying products diniconazole.