Methoprene

Methoprene 

CAS :36557-27-4 

English name: Methoprene 

Chemical Name: (E, E) - (RS) -11 - methoxy -3,7,11 - trimethyl-dodecyl 2,4 - bis acid isopropyl; (E, E) - (± )-1-methylethyl 11-methoxy-3 ,7,11-trimethyl-2 ,4-dodecadienoate 

Other names: allyl ester insects, pest pouring Lini, can protect special [Sandoz], control insect hormone, juvenile hormone methoxy 

Molecular formula: C19H34O2 

Molecular weight: 310.5 

Structure: 

Physical and chemical properties: the original drug to pale yellow oily liquid, density 0.9261g/mL (20 ℃), boiling point 100 ℃ (0.05mmHg), melting point -20 ℃, vapor pressure of 2.37 * 10 ^ (-5) mmHg (25 ℃), Solubility in water, 1.4mg / L., miscible with most organic solvents. 

Toxicity LD50/LC50: Acute Oral:> 34600mg/kg; Acute dermal :3000-10000mg / kg (rabbit). Chicken LC50 (8 天)> 4640 mg / kg, blue gill sunfish LC50 (96 h) 4.6 mg / l,, rainbow trout 4.4 mg / l, bee LD50> 1000 μg / only. 

Role of the characteristics and uses: the 20th century, emerged 70 insect growth regulator, juvenile hormone analogues. Protective agent for the tobacco drug is a synthetic analogue of insect poison, insect molting process of interference. It can interfere with the tobacco beetle, tobacco moth growth and development process, so that adults lose their reproductive capacity to effectively control population growth of stored tobacco insect pests. On the Lepidoptera, Diptera, Coleoptera, Homoptera variety of insects effective for the control of mosquitoes, flies and other health pests, and tobacco Minge and other pests during storage. 

Formulation: 4.1% soluble liquid, cream, granules, sustained-release agent. 

Production Methods: citronellal as starting material and Reformatskii aldol condensation reaction of 3,7,11 - trimethyl -2,4,10 - twelve carbon triple acid cis-trans double bond of isopropyl isomer mixture, the thiophenol two catalytic double bond isomerization, (2E, 4E) - 3a isomer content from 26% to 85%. and then through the ether reaction, stereoselective to total synthesis of a juvenile hormone activity with insect growth regulators methoprene and its isomers, or 11. methoxy .3,7,11 - trimethyl -2,4 - two acid dodecyl isopropyl. which has a high biological activity of (2E, 4E) - isomer content of up to 85%